This technology allows one to precisely manipulate virtually any genomic sequence specified by a short stretch of guide … This interactive module explores how CRISPR-Cas9 technology works and the many ways in which scientists are using it in their research. Made up of a DNA-cutting enzyme (Cas9) and a programmable RNA molecule (guide RNA), CRISPR-Cas9 can be used to precisely target nearly any ge ne. This interactive allows high school and undergraduate students and science educators to explore the structure and function of the CRISPR Cas9-guide RNA complex and its interactions with DNA, learn about DNA repair mechanisms, and view a series of videos on applications of CRISPR with a diverse group of scientists that use this revolutionary tool. Websites. CRISPR-Cas9: Mechanism & Applications. The interactive is designed to accompany curricula for courses ranging from first-year high school biology, to undergraduate introductory biology, and various upper-level molecular biology and biotechnology courses. The interactive includes a dynamic and responsive self-paced scrolling molecular animation that divides CRISPR actions into distinct didactic stages: targeting, binding, cleaving, and DNA repair. Since it was first described in 2012, CRISPR-Cas9 (often shortened to “CRISPR”) has generated much interest and excitement. HHMI BioInteractive & AXS Studio. Students can explore information in a variety of formats such as cross-sectional views of the molecules with detailed descriptions of function and short summaries of the research studies linked to scientific papers. Lorem ipsum dolor sit amet, consectateur adisciping Lorem ipsum dolor sit amet, consectateur adisciping. This interactive allows high school and undergraduate students and science educators to explore the structure and function of the CRISPR Cas9-guide RNA complex and its interactions with DNA, learn about DNA repair mechanisms, and view a series of videos on applications of CRISPR with a diverse group of scientists that use this revolutionary tool. This is a video about CRISPR. CRISPR-Cas9: Mechanism and Applications CRISPR-Cas9 is a type of immune system discovered in bacteria. Target reco … Scientists have adapted its components into a biotechnology tool for editing DNA. The clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein 9 (Cas9) system, a bacterial defense mechanism against phage infection and plasmid transfer in nature (Figure 1), has been repurposed as a powerful RNA-guided DNA targeting platform for genome editing, transcriptional perturbation, epigenetic modulation, and genome imaging (Figure 2). © 2018 Association of Medical Illustrators. Project Description. Many bacterial clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated (Cas) systems employ the dual RNA-guided DNA endonuclease Cas9 to defend against invading phages and conjugative plasmids by introducing site-specific double-stranded breaks in target DNA.